1.1M XNAS Volume
XNAS 24 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Matthew C. Kapusta | Director, CEO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 171,000 | 171,000 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, Managing Director | Sale of securities on an exchange or to another person at price $ 10.29 per share. | 03 Mar 2025 | 28,341 | 651,454 (1%) | 0% | 10.3 | 291,629 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 99,000 | 679,795 (1%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 73,000 | 228,168 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 126,000 | 126,000 | - | - | Stock Option (Right to Buy) | |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.29 per share. | 03 Mar 2025 | 10,438 | 217,730 (0%) | 0% | 10.3 | 107,407 | Ordinary Shares |
| Walid Abi-Saab | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 38,000 | 153,253 (0%) | 0% | 0 | Ordinary Shares | |
| Walid Abi-Saab | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 10.29 per share. | 03 Mar 2025 | 1,350 | 151,903 (0%) | 0% | 10.3 | 13,892 | Ordinary Shares |
| Walid Abi-Saab | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 66,000 | 66,000 | - | - | Stock Option (Right to Buy) | |
| Jeannette Potts | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 35,000 | 126,819 (0%) | 0% | 0 | Ordinary Shares | |
| Jeannette Potts | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Jeannette Potts | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 10.29 per share. | 03 Mar 2025 | 7,076 | 119,743 (0%) | 0% | 10.3 | 72,812 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Sale of securities on an exchange or to another person at price $ 10.70 per share. | 25 Feb 2025 | 26,727 | 571,188 (1%) | 0% | 10.7 | 285,979 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 16,324 | 587,512 (1%) | 0% | 0 | Ordinary Shares | |
| Matthew C. Kapusta | Director, CEO, Managing Director | Sale of securities on an exchange or to another person at price $ 11.32 per share. | 25 Feb 2025 | 6,717 | 580,795 (1%) | 0% | 11.3 | 76,036 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.70 per share. | 25 Feb 2025 | 14,341 | 152,372 (0%) | 0% | 10.7 | 153,449 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 5,712 | 158,084 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 11.32 per share. | 25 Feb 2025 | 2,916 | 155,168 (0%) | 0% | 11.3 | 33,009 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.71 per share. | 10 Dec 2024 | 100,000 | 697,915 (1%) | 0% | 14.7 | 1,471,000 | Ordinary Shares |
| Kapusta C. Matthew | Director, CEO, Managing Director | Sale of securities on an exchange or to another person at price $ 15.03 per share. | 10 Dec 2024 | 100,000 | 597,915 (1%) | 0% | 15.0 | 1,503,000 | Ordinary Shares |
| Kapusta C. Matthew | Director, CEO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 100,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, Managing Director | Sale of securities on an exchange or to another person at price $ 7.63 per share. | 08 Dec 2024 | 3,418 | 597,915 (1%) | 0% | 7.6 | 26,079 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2024 | 10,494 | 601,333 (1%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 7.55 per share. | 08 Dec 2024 | 1,796 | 166,713 (0%) | 0% | 7.6 | 13,560 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2024 | 3,672 | 168,509 (0%) | 0% | 0 | Ordinary Shares | |
| Walid Abi-Saab | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 4.36 per share. | 26 Jun 2024 | 1,447 | 115,253 (0%) | 0% | 4.4 | 6,309 | Ordinary Shares |
| Jack L. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 15,840 | 15,840 | - | - | Stock Option (Right to Buy) | |
| Jack L. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 8,080 | 14,581 (0%) | 0% | 0 | Ordinary Shares | |
| Leonard E. Post | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 8,080 | 24,079 (0%) | 0% | 0 | Ordinary Shares | |
| Leonard E. Post | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 15,840 | 15,840 | - | - | Stock Option (Right to Buy) | |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 15,840 | 15,840 | - | - | Stock Option (Right to Buy) | |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 8,080 | 31,839 (0%) | 0% | 0 | Ordinary Shares | |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 15,840 | 15,840 | - | - | Stock Option (Right to Buy) | |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 8,080 | 28,332 (0%) | 0% | 0 | Ordinary Shares | |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 15,840 | 15,840 | - | - | Stock Option (Right to Buy) | |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 8,080 | 31,836 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Gut | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 8,080 | 52,245 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Gut | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 15,840 | 15,840 | - | - | Stock Option (Right to Buy) | |
| Rachelle S. Jacques | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 15,840 | 15,840 | - | - | Stock Option (Right to Buy) | |
| Rachelle S. Jacques | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2024 | 8,080 | 22,488 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 4.80 per share. | 17 Jun 2024 | 1,611 | 164,837 (0%) | 0% | 4.8 | 7,733 | Ordinary Shares |
| Pierre Caloz | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 4.81 per share. | 17 Jun 2024 | 2,936 | 115,707 (0%) | 0% | 4.8 | 14,122 | Ordinary Shares |
| Jack L. Kaye | Director | Sale of securities on an exchange or to another person at price $ 5.16 per share. | 13 Jun 2024 | 2,218 | 6,501 (0%) | 0% | 5.2 | 11,445 | Ordinary Shares |
| Madhu Balachandran | Director | Sale of securities on an exchange or to another person at price $ 5.12 per share. | 13 Jun 2024 | 2,231 | 23,759 (0%) | 0% | 5.1 | 11,423 | Ordinary Shares |
| David D. Meek | Director | Sale of securities on an exchange or to another person at price $ 5.12 per share. | 13 Jun 2024 | 2,229 | 20,252 (0%) | 0% | 5.1 | 11,412 | Ordinary Shares |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 5.14 per share. | 13 Jun 2024 | 2,220 | 20,203 (0%) | 0% | 5.1 | 11,411 | Ordinary Shares |
| Jeremy P. Springhorn | Director | Sale of securities on an exchange or to another person at price $ 5.12 per share. | 13 Jun 2024 | 2,231 | 23,756 (0%) | 0% | 5.1 | 11,423 | Ordinary Shares |
| Robert Gut | Director | Sale of securities on an exchange or to another person at price $ 5.12 per share. | 13 Jun 2024 | 3,504 | 44,165 (0%) | 0% | 5.1 | 17,940 | Ordinary Shares |
| Rachelle S. Jacques | Director | Sale of securities on an exchange or to another person at price $ 5.14 per share. | 13 Jun 2024 | 2,221 | 14,408 (0%) | 0% | 5.1 | 11,416 | Ordinary Shares |
| Jeannette Potts | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 4.98 per share. | 13 Jun 2024 | 4,781 | 91,819 (0%) | 0% | 5.0 | 23,809 | Ordinary Shares |
| Leonard E. Post | Director | Sale of securities on an exchange or to another person at price $ 5.14 per share. | 13 Jun 2024 | 2,222 | 15,999 (0%) | 0% | 5.1 | 11,421 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 259,500 | 259,500 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 150,000 | 590,839 (1%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 49,500 | 166,448 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 85,500 | 85,500 | - | - | Stock Option (Right to Buy) | |
| Walid Abi-Saab | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 85,500 | 85,500 | - | - | Stock Option (Right to Buy) | |
| Walid Abi-Saab | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 49,500 | 116,700 (0%) | 0% | 0 | Ordinary Shares | |
| Pierre Caloz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 57,000 | 57,000 | - | - | Stock Option (Right to Buy) | |
| Pierre Caloz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 33,000 | 118,643 (0%) | 0% | 0 | Ordinary Shares | |
| Jeannette Potts | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 85,500 | 85,500 | - | - | Stock Option (Right to Buy) | |
| Jeannette Potts | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 49,500 | 96,600 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 6.38 per share. | 26 Feb 2024 | 15,906 | 116,948 (0%) | 0% | 6.4 | 101,480 | Ordinary Shares |
| C. Matthew Kapusta | Director, CEO, Managing Director | Sale of securities on an exchange or to another person at price $ 6.35 per share. | 26 Feb 2024 | 27,904 | 440,839 (0%) | 0% | 6.3 | 177,190 | Ordinary Shares |
| Pierre Caloz | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 6.47 per share. | 26 Feb 2024 | 9,455 | 85,643 (0%) | 0% | 6.5 | 61,174 | Ordinary Shares |
| Pierre Caloz | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 11.36 per share. | 10 Jul 2023 | 15,117 | 95,098 (0%) | 0% | 11.4 | 171,729 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.94 per share. | 16 Jun 2023 | 1,587 | 132,854 (0%) | 0% | 18.9 | 30,058 | Ordinary Shares |
| Pierre Caloz | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.80 per share. | 16 Jun 2023 | 2,920 | 110,215 (0%) | 0% | 18.8 | 54,896 | Ordinary Shares |
| Jack L. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 17,060 | 17,060 | - | - | Stock Option (Right to Buy) | |
| Jack L. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 8,700 | 36,399 (0%) | 0% | 0 | Ordinary Shares | |
| Jack L. Kaye | Director | Sale of securities on an exchange or to another person at price $ 18.93 per share. | 13 Jun 2023 | 2,280 | 34,119 (0%) | 0% | 18.9 | 43,160 | Ordinary Shares |
| Leonard E. Post | Director | Sale of securities on an exchange or to another person at price $ 18.83 per share. | 13 Jun 2023 | 2,291 | 18,221 (0%) | 0% | 18.8 | 43,140 | Ordinary Shares |
| Leonard E. Post | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 17,060 | 17,060 | - | - | Stock Option (Right to Buy) | |
| Leonard E. Post | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 8,700 | 20,512 (0%) | 0% | 0 | Ordinary Shares | |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 8,700 | 28,273 (0%) | 0% | 0 | Ordinary Shares | |
| Madhu Balachandran | Director | Sale of securities on an exchange or to another person at price $ 18.91 per share. | 13 Jun 2023 | 2,283 | 25,990 (0%) | 0% | 18.9 | 43,172 | Ordinary Shares |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 17,060 | 17,060 | - | - | Stock Option (Right to Buy) | |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 17,060 | 17,060 | - | - | Stock Option (Right to Buy) | |
| David D. Meek | Director | Sale of securities on an exchange or to another person at price $ 18.85 per share. | 13 Jun 2023 | 2,290 | 22,481 (0%) | 0% | 18.9 | 43,167 | Ordinary Shares |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 8,700 | 24,771 (0%) | 0% | 0 | Ordinary Shares | |
| Paula Soteropoulos | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 17,060 | 17,060 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 8,700 | 24,698 (0%) | 0% | 0 | Ordinary Shares | |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 18.99 per share. | 13 Jun 2023 | 2,275 | 22,423 (0%) | 0% | 19.0 | 43,202 | Ordinary Shares |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 17,060 | 17,060 | - | - | Stock Option (Right to Buy) | |
| Jeremy P. Springhorn | Director | Sale of securities on an exchange or to another person at price $ 18.88 per share. | 13 Jun 2023 | 2,286 | 25,987 (0%) | 0% | 18.9 | 43,160 | Ordinary Shares |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 8,700 | 28,273 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Gut | Director | Sale of securities on an exchange or to another person at price $ 18.88 per share. | 13 Jun 2023 | 3,228 | 47,669 (0%) | 0% | 18.9 | 60,945 | Ordinary Shares |
| Robert Gut | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 8,700 | 50,897 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Gut | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 17,060 | 17,060 | - | - | Stock Option (Right to Buy) | |
| Rachelle Jacques | Director | Sale of securities on an exchange or to another person at price $ 18.76 per share. | 13 Jun 2023 | 2,301 | 16,629 (0%) | 0% | 18.8 | 43,167 | Ordinary Shares |
| Rachelle Jacques | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 17,060 | 17,060 | - | - | Stock Option (Right to Buy) | |
| Rachelle Jacques | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 8,700 | 18,930 (0%) | 0% | 0 | Ordinary Shares | |
| Matthew C. Kapusta | Director, CEO, Managing Director | Sale of securities on an exchange or to another person at price $ 21.39 per share. | 07 Mar 2023 | 2,521 | 468,743 (1%) | 0% | 21.4 | 53,924 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 21.36 per share. | 07 Mar 2023 | 585 | 90,381 (0%) | 0% | 21.4 | 12,496 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 21.36 per share. | 07 Mar 2023 | 986 | 134,441 (0%) | 0% | 21.4 | 21,061 | Ordinary Shares |
| Ricardo Dolmetsch | President, R&D | Sale of securities on an exchange or to another person at price $ 21.04 per share. | 07 Mar 2023 | 837 | 169,245 (0%) | 0% | 21.0 | 17,610 | Ordinary Shares |
| Pierre Caloz | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 21.33 per share. | 07 Mar 2023 | 990 | 113,135 (0%) | 0% | 21.3 | 21,117 | Ordinary Shares |
| Jack L. Kaye | Director | Sale of securities on an exchange or to another person at price $ 19.99 per share. | 27 Feb 2023 | 384 | 27,699 (0%) | 0% | 20.0 | 7,676 | Ordinary Shares |
| Leonard E. Post | Director | Sale of securities on an exchange or to another person at price $ 19.73 per share. | 27 Feb 2023 | 389 | 11,812 (0%) | 0% | 19.7 | 7,675 | Ordinary Shares |
| Madhu Balachandran | Director | Sale of securities on an exchange or to another person at price $ 19.99 per share. | 27 Feb 2023 | 384 | 19,573 (0%) | 0% | 20.0 | 7,676 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Sale of securities on an exchange or to another person at price $ 19.86 per share. | 27 Feb 2023 | 18,141 | 477,670 (1%) | 0% | 19.9 | 360,280 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Sale of securities on an exchange or to another person at price $ 20.90 per share. | 27 Feb 2023 | 5,021 | 471,264 (1%) | 0% | 20.9 | 104,939 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Sale of securities on an exchange or to another person at price $ 20.24 per share. | 27 Feb 2023 | 1,385 | 476,285 (1%) | 0% | 20.2 | 28,032 | Ordinary Shares |
| David D. Meek | Director | Sale of securities on an exchange or to another person at price $ 19.71 per share. | 27 Feb 2023 | 389 | 16,071 (0%) | 0% | 19.7 | 7,667 | Ordinary Shares |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 19.97 per share. | 27 Feb 2023 | 384 | 15,998 (0%) | 0% | 20.0 | 7,668 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 21.04 per share. | 27 Feb 2023 | 1,212 | 90,966 (0%) | 0% | 21.0 | 25,500 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 19.99 per share. | 27 Feb 2023 | 5,514 | 92,178 (0%) | 0% | 20.0 | 110,225 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.90 per share. | 27 Feb 2023 | 1,369 | 135,427 (0%) | 0% | 20.9 | 28,612 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.10 per share. | 27 Feb 2023 | 9,824 | 136,796 (0%) | 0% | 20.1 | 197,462 | Ordinary Shares |
| Jeremy P. Springhorn | Director | Sale of securities on an exchange or to another person at price $ 20.41 per share. | 27 Feb 2023 | 384 | 19,573 (0%) | 0% | 20.4 | 7,837 | Ordinary Shares |
| Robert Gut | Director | Sale of securities on an exchange or to another person at price $ 21.16 per share. | 27 Feb 2023 | 1,431 | 42,197 (0%) | 0% | 21.2 | 30,280 | Ordinary Shares |
| Robert Gut | Director | Sale of securities on an exchange or to another person at price $ 19.79 per share. | 27 Feb 2023 | 537 | 43,628 (0%) | 0% | 19.8 | 10,627 | Ordinary Shares |
| Rachelle Jacques | Director | Sale of securities on an exchange or to another person at price $ 20.02 per share. | 27 Feb 2023 | 384 | 10,230 (0%) | 0% | 20.0 | 7,688 | Ordinary Shares |
| Ricardo Dolmetsch | President, R&D | Sale of securities on an exchange or to another person at price $ 19.58 per share. | 27 Feb 2023 | 6,944 | 170,082 (0%) | 0% | 19.6 | 135,964 | Ordinary Shares |
| Pierre Caloz | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 20.80 per share. | 27 Feb 2023 | 81 | 114,125 (0%) | 0% | 20.8 | 1,685 | Ordinary Shares |
| Pierre Caloz | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.59 per share. | 27 Feb 2023 | 4,284 | 114,206 (0%) | 0% | 19.6 | 83,924 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2023 | 121,500 | 495,811 (1%) | 0% | 0 | Ordinary Shares | |
| Matthew C. Kapusta | Director, CEO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2023 | 256,500 | 256,500 | - | - | Stock Option (Right to Buy) | |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2023 | 64,500 | 64,500 | - | - | Stock Option (Right to Buy) | |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2023 | 37,400 | 146,620 (0%) | 0% | 0 | Ordinary Shares | |
| Ricardo Dolmetsch | President, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2023 | 80,600 | 80,600 | - | - | Stock Option (Right to Buy) | |
| Ricardo Dolmetsch | President, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2023 | 46,700 | 177,026 (0%) | 0% | 0 | Ordinary Shares | |
| Pierre Caloz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2023 | 46,700 | 118,490 (0%) | 0% | 0 | Ordinary Shares | |
| Pierre Caloz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2023 | 80,600 | 80,600 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 5,830 | 374,311 (0%) | 0% | 0 | Ordinary Shares | |
| Alexander Edward Kuta | Executive VP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 2,040 | 97,692 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 2,040 | 109,220 (0%) | 0% | 0 | Ordinary Shares | |
| Ricardo Dolmetsch | President, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 2,920 | 130,326 (0%) | 0% | 0 | Ordinary Shares | |
| Pierre Caloz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 2,920 | 71,790 (0%) | 0% | 0 | Ordinary Shares | |
| Paula Soteropoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.37 per share. | 18 Jan 2023 | 6,000 | 22,382 (0%) | 0% | 5.4 | 32,220 | Ordinary Shares |
| Paula Soteropoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jan 2023 | 6,000 | 2,000 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 22.59 per share. | 18 Jan 2023 | 6,000 | 16,382 (0%) | 0% | 22.6 | 135,540 | Ordinary Shares |
| Paula Soteropoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.37 per share. | 13 Dec 2022 | 3,000 | 19,382 (0%) | 0% | 5.4 | 16,110 | Ordinary Shares |
| Paula Soteropoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2022 | 3,800 | 0 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2022 | 3,000 | 8,000 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 23.43 per share. | 13 Dec 2022 | 3,800 | 16,382 (0%) | 0% | 23.4 | 89,034 | Ordinary Shares |
| Paula Soteropoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2022 | 3,800 | 20,182 (0%) | 0% | - | Ordinary Shares | |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 23.45 per share. | 13 Dec 2022 | 3,000 | 16,382 (0%) | 0% | 23.5 | 70,350 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Sale of securities on an exchange or to another person at price $ 22.44 per share. | 09 Dec 2022 | 6,648 | 368,481 (0%) | 0% | 22.4 | 149,181 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 22.34 per share. | 09 Dec 2022 | 2,338 | 95,652 (0%) | 0% | 22.3 | 52,231 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 22.35 per share. | 09 Dec 2022 | 2,608 | 107,180 (0%) | 0% | 22.4 | 58,289 | Ordinary Shares |
| Ricardo Dolmetsch | President, R&D | Sale of securities on an exchange or to another person at price $ 22.30 per share. | 09 Dec 2022 | 2,219 | 127,406 (0%) | 0% | 22.3 | 49,484 | Ordinary Shares |
| Pierre Caloz | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 22.22 per share. | 09 Dec 2022 | 2,941 | 68,870 (0%) | 0% | 22.2 | 65,349 | Ordinary Shares |
| Paula Soteropoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2022 | 6,200 | 22,582 (0%) | 0% | - | Ordinary Shares | |
| Paula Soteropoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2022 | 6,200 | 3,800 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 25.38 per share. | 29 Nov 2022 | 6,200 | 16,382 (0%) | 0% | 25.4 | 157,356 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Nov 2022 | 14,575 | 375,129 (0%) | 0% | 0 | Ordinary Shares | |
| Alexander Edward Kuta | Executive VP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Nov 2022 | 5,100 | 97,990 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Nov 2022 | 5,100 | 109,788 (0%) | 0% | 0 | Ordinary Shares | |
| Ricardo Dolmetsch | President, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Nov 2022 | 7,300 | 129,625 (0%) | 0% | 0 | Ordinary Shares | |
| Pierre Caloz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Nov 2022 | 7,300 | 71,811 (0%) | 0% | 0 | Ordinary Shares | |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 18.65 per share. | 21 Sep 2022 | 2,306 | 92,890 (0%) | 0% | 18.7 | 43,007 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 27 Jul 2022 | 10,404 | 95,196 (0%) | 0% | 25 | 260,100 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jul 2022 | 27,358 | 0 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jul 2022 | 10,404 | 27,358 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 25.01 per share. | 27 Jul 2022 | 406 | 95,196 (0%) | 0% | 25.0 | 10,154 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 27 Jul 2022 | 26,952 | 95,602 (0%) | 0% | 25 | 673,800 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 27 Jul 2022 | 27,358 | 122,554 (0%) | 0% | 5.3 | 145,271 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 27 Jul 2022 | 10,404 | 105,600 (0%) | 0% | 5.3 | 55,245 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 21 Jul 2022 | 595 | 95,791 (0%) | 0% | 5.3 | 3,159 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2022 | 5,643 | 37,762 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2022 | 595 | 43,405 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 21 Jul 2022 | 5,643 | 95,196 (0%) | 0% | 25 | 141,075 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 21 Jul 2022 | 5,643 | 100,839 (0%) | 0% | 5.3 | 29,964 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 21 Jul 2022 | 595 | 95,196 (0%) | 0% | 25 | 14,875 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 13.20 per share. | 16 Jun 2022 | 1,687 | 104,688 (0%) | 0% | 13.2 | 22,268 | Ordinary Shares |
| Pierre Caloz | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 13.21 per share. | 16 Jun 2022 | 7,575 | 64,511 (0%) | 0% | 13.2 | 100,066 | Ordinary Shares |
| Jack L. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 17,810 | 17,810 | - | - | Stock Option (Right to Buy) | |
| Jack L. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 9,080 | 28,083 (0%) | 0% | 0 | Ordinary Shares | |
| Leonard E. Post | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 9,080 | 12,201 (0%) | 0% | 0 | Ordinary Shares | |
| Leonard E. Post | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 17,810 | 17,810 | - | - | Stock Option (Right to Buy) | |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 9,080 | 19,957 (0%) | 0% | 0 | Ordinary Shares | |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 17,810 | 17,810 | - | - | Stock Option (Right to Buy) | |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 9,080 | 16,460 (0%) | 0% | 0 | Ordinary Shares | |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 17,810 | 17,810 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 17,810 | 17,810 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 9,080 | 16,382 (0%) | 0% | 0 | Ordinary Shares | |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 9,080 | 19,957 (0%) | 0% | 0 | Ordinary Shares | |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 17,810 | 17,810 | - | - | Stock Option (Right to Buy) | |
| Robert Gut | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 9,080 | 44,165 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Gut | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 17,810 | 17,810 | - | - | Stock Option (Right to Buy) | |
| Rachelle Jacques | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 17,810 | 17,810 | - | - | Stock Option (Right to Buy) | |
| Rachelle Jacques | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2022 | 9,080 | 10,614 (0%) | 0% | 0 | Ordinary Shares | |
| Jack L. Kaye | Director | Sale of securities on an exchange or to another person at price $ 16.76 per share. | 28 Feb 2022 | 600 | 19,003 (0%) | 0% | 16.8 | 10,056 | Ordinary Shares |
| Leonard E. Post | Director | Sale of securities on an exchange or to another person at price $ 16.64 per share. | 28 Feb 2022 | 795 | 3,121 (0%) | 0% | 16.6 | 13,229 | Ordinary Shares |
| Madhu Balachandran | Director | Sale of securities on an exchange or to another person at price $ 16.70 per share. | 28 Feb 2022 | 602 | 10,877 (0%) | 0% | 16.7 | 10,053 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO & Managing Director | Sale of securities on an exchange or to another person at price $ 16.70 per share. | 28 Feb 2022 | 10,195 | 360,554 (0%) | 0% | 16.7 | 170,257 | Ordinary Shares |
| David D. Meek | Director | Sale of securities on an exchange or to another person at price $ 16.70 per share. | 28 Feb 2022 | 602 | 7,380 (0%) | 0% | 16.7 | 10,053 | Ordinary Shares |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 16.87 per share. | 28 Feb 2022 | 596 | 7,302 (0%) | 0% | 16.9 | 10,055 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 16.72 per share. | 28 Feb 2022 | 3,405 | 95,156 (0%) | 0% | 16.7 | 56,932 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 16.80 per share. | 28 Feb 2022 | 4,075 | 106,375 (0%) | 0% | 16.8 | 68,460 | Ordinary Shares |
| Jeremy P. Springhorn | Director | Sale of securities on an exchange or to another person at price $ 16.70 per share. | 28 Feb 2022 | 602 | 10,877 (0%) | 0% | 16.7 | 10,053 | Ordinary Shares |
| Robert Gut | Director | Sale of securities on an exchange or to another person at price $ 16.70 per share. | 28 Feb 2022 | 1,602 | 35,085 (0%) | 0% | 16.7 | 26,753 | Ordinary Shares |
| Ricardo Dolmetsch | President, R&D | Sale of securities on an exchange or to another person at price $ 16.68 per share. | 28 Feb 2022 | 1,484 | 122,325 (0%) | 0% | 16.7 | 24,753 | Ordinary Shares |
| Jack L. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,645 | 2,645 | - | - | Stock Option (Right to Buy) | |
| Jack L. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 1,534 | 19,603 (0%) | 0% | 0 | Ordinary Shares | |
| Leonard E. Post | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 1,534 | 3,916 (0%) | 0% | 0 | Ordinary Shares | |
| Leonard E. Post | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,645 | 2,645 | - | - | Stock Option (Right to Buy) | |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,645 | 2,645 | - | - | Stock Option (Right to Buy) | |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 1,534 | 11,479 (0%) | 0% | 0 | Ordinary Shares | |
| Matthew C. Kapusta | Director, CEO and Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 215,643 | 215,643 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO and Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 125,073 | 370,749 (0%) | 0% | 0 | Ordinary Shares | |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,645 | 2,645 | - | - | Stock Option (Right to Buy) | |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 1,534 | 7,982 (0%) | 0% | 0 | Ordinary Shares | |
| Paula Soteropoulos | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,645 | 2,645 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 1,534 | 7,898 (0%) | 0% | 0 | Ordinary Shares | |
| Alexander Edward Kuta | Executive VP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 60,179 | 60,179 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 34,904 | 98,601 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 43,630 | 110,450 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 75,224 | 75,224 | - | - | Stock Option (Right to Buy) | |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 1,534 | 11,479 (0%) | 0% | 0 | Ordinary Shares | |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,645 | 2,645 | - | - | Stock Option (Right to Buy) | |
| Robert Gut | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 1,534 | 36,687 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Gut | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,645 | 2,645 | - | - | Stock Option (Right to Buy) | |
| Rachelle Jacques | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 1,534 | 1,534 (0%) | 0% | 0 | Ordinary Shares | |
| Rachelle Jacques | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,645 | 2,645 | - | - | Stock Option (Right to Buy) | |
| Ricardo Dolmetsch | President, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 54,683 | 123,809 (0%) | 0% | 0 | Ordinary Shares | |
| Ricardo Dolmetsch | President, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 94,281 | 94,281 | - | - | Stock Option (Right to Buy) | |
| Pierre Caloz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 63,941 | 63,941 | - | - | Stock Option (Right to Buy) | |
| Pierre Caloz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 37,086 | 72,086 (0%) | 0% | 0 | Ordinary Shares | |
| Matthew C. Kapusta | CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 18.10 per share. | 26 Jan 2022 | 10,901 | 245,676 (0%) | 0% | 18.1 | 197,308 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 18.02 per share. | 26 Jan 2022 | 2,945 | 63,697 (0%) | 0% | 18.0 | 53,069 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.03 per share. | 26 Jan 2022 | 3,963 | 66,820 (0%) | 0% | 18.0 | 71,453 | Ordinary Shares |
| Robert Gut | Director | Sale of securities on an exchange or to another person at price $ 18.12 per share. | 26 Jan 2022 | 2,348 | 35,153 (0%) | 0% | 18.1 | 42,546 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2021 | 6,000 | 44,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 27.90 per share. | 15 Dec 2021 | 6,000 | 66,642 (0%) | 0% | 27.9 | 167,400 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 15 Dec 2021 | 6,000 | 72,642 (0%) | 0% | 5.3 | 31,860 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 15 Nov 2021 | 6,000 | 72,642 (0%) | 0% | 5.3 | 31,860 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2021 | 6,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 31.81 per share. | 15 Nov 2021 | 6,000 | 66,642 (0%) | 0% | 31.8 | 190,860 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 30.65 per share. | 15 Oct 2021 | 6,000 | 66,642 (0%) | 0% | 30.7 | 183,900 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2021 | 6,000 | 56,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 15 Oct 2021 | 6,000 | 72,642 (0%) | 0% | 5.3 | 31,860 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 36.71 per share. | 21 Sep 2021 | 2,229 | 66,642 (0%) | 0% | 36.7 | 81,827 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 38.00 per share. | 21 Sep 2021 | 2,400 | 70,783 (0%) | 0% | 38 | 91,200 | Ordinary Shares |
| Robert Gut | Director | Sale of securities on an exchange or to another person at price $ 36.61 per share. | 21 Sep 2021 | 4,500 | 37,501 (0%) | 0% | 36.6 | 164,745 | Ordinary Shares |
| Ricardo Dolmetsch | President, R&D | Sale of securities on an exchange or to another person at price $ 37.10 per share. | 16 Sep 2021 | 8,603 | 69,126 (0%) | 0% | 37.1 | 319,171 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 36.32 per share. | 15 Sep 2021 | 6,000 | 68,871 (0%) | 0% | 36.3 | 217,920 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Sep 2021 | 6,000 | 62,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 15 Sep 2021 | 6,000 | 74,871 (0%) | 0% | 5.3 | 31,860 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 28.64 per share. | 18 Aug 2021 | 117 | 256,577 (0%) | 0% | 28.6 | 3,351 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 28.08 per share. | 18 Aug 2021 | 883 | 256,694 (0%) | 0% | 28.1 | 24,795 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 28.84 per share. | 16 Aug 2021 | 6,000 | 68,871 (0%) | 0% | 28.8 | 173,040 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2021 | 6,000 | 68,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 16 Aug 2021 | 6,000 | 74,871 (0%) | 0% | 5.3 | 31,860 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 27.22 per share. | 15 Jul 2021 | 6,000 | 68,871 (0%) | 0% | 27.2 | 163,320 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 15 Jul 2021 | 6,000 | 74,871 (0%) | 0% | 5.3 | 31,860 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2021 | 6,000 | 74,000 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 27.77 per share. | 14 Jul 2021 | 1,000 | 257,577 (0%) | 0% | 27.8 | 27,770 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 34.26 per share. | 16 Jun 2021 | 1,457 | 262,470 (0%) | 0% | 34.3 | 49,917 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 16 Jun 2021 | 1,900 | 258,577 (0%) | 0% | 35 | 66,500 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 34.89 per share. | 16 Jun 2021 | 1,993 | 260,477 (0%) | 0% | 34.9 | 69,536 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 15 Jun 2021 | 6,000 | 74,871 (0%) | 0% | 5.3 | 31,860 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jun 2021 | 6,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 35.43 per share. | 15 Jun 2021 | 6,000 | 68,871 (0%) | 0% | 35.4 | 212,580 | Ordinary Shares |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 16,235 | 16,235 | - | - | Stock Option (Right to Buy) | |
| Christian Klemt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 9,579 | 73,183 (0%) | 0% | 0 | Ordinary Shares | |
| Pierre Caloz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 25,000 | 35,000 (0%) | 0% | 0 | Ordinary Shares | |
| Pierre Caloz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 75,000 | 75,000 | - | - | Stock option (Right to Buy) | |
| Pierre Caloz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 10,000 | 10,000 (0%) | 0% | 0 | Ordinary Shares | |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 17 May 2021 | 6,000 | 74,871 (0%) | 0% | 5.3 | 31,860 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2021 | 6,000 | 86,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 31.66 per share. | 17 May 2021 | 6,000 | 68,871 (0%) | 0% | 31.7 | 189,960 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 32.29 per share. | 12 May 2021 | 2,250 | 263,927 (0%) | 0% | 32.3 | 72,653 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 35.06 per share. | 15 Apr 2021 | 6,000 | 68,871 (0%) | 0% | 35.1 | 210,360 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2021 | 6,000 | 92,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 15 Apr 2021 | 6,000 | 74,871 (0%) | 0% | 5.3 | 31,860 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 35.59 per share. | 14 Apr 2021 | 1,718 | 266,177 (0%) | 0% | 35.6 | 61,144 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 35.07 per share. | 14 Apr 2021 | 3,632 | 267,895 (0%) | 0% | 35.1 | 127,374 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 34.50 per share. | 17 Mar 2021 | 6 | 271,527 (0%) | 0% | 34.5 | 207 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 32.95 per share. | 17 Mar 2021 | 1,788 | 271,989 (0%) | 0% | 33.0 | 58,915 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 33.98 per share. | 17 Mar 2021 | 456 | 271,533 (0%) | 0% | 34.0 | 15,495 | Ordinary Shares |
| Jack L. Kaye | Director | Sale of securities on an exchange or to another person at price $ 37.60 per share. | 02 Mar 2021 | 504 | 18,069 (0%) | 0% | 37.6 | 18,950 | Ordinary Shares |
| Madhu Balachandran | Director | Sale of securities on an exchange or to another person at price $ 37.50 per share. | 02 Mar 2021 | 505 | 9,945 (0%) | 0% | 37.5 | 18,938 | Ordinary Shares |
| Matthew C. Kapusta | CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 36.94 per share. | 02 Mar 2021 | 4,974 | 273,777 (0%) | 0% | 36.9 | 183,740 | Ordinary Shares |
| David D. Meek | Director | Sale of securities on an exchange or to another person at price $ 37.50 per share. | 02 Mar 2021 | 505 | 6,448 (0%) | 0% | 37.5 | 18,938 | Ordinary Shares |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 37.60 per share. | 02 Mar 2021 | 504 | 6,364 (0%) | 0% | 37.6 | 18,950 | Ordinary Shares |
| Philip Astley-Sparke | Director | Sale of securities on an exchange or to another person at price $ 37.60 per share. | 02 Mar 2021 | 504 | 9,946 (0%) | 0% | 37.6 | 18,950 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 37.00 per share. | 02 Mar 2021 | 1,206 | 68,871 (0%) | 0% | 37 | 44,622 | Ordinary Shares |
| Christian Klemt | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 37.03 per share. | 02 Mar 2021 | 1,350 | 63,604 (0%) | 0% | 37.0 | 49,991 | Ordinary Shares |
| Jeremy P. Springhorn | Director | Sale of securities on an exchange or to another person at price $ 37.50 per share. | 02 Mar 2021 | 505 | 9,945 (0%) | 0% | 37.5 | 18,938 | Ordinary Shares |
| Robert Gut | Director | Sale of securities on an exchange or to another person at price $ 36.98 per share. | 02 Mar 2021 | 1,300 | 42,001 (0%) | 0% | 37.0 | 48,074 | Ordinary Shares |
| Jack L. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 4,107 | 4,107 | - | - | Stock Option (Right to Buy) | |
| Jack L. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 2,382 | 18,573 (0%) | 0% | 0 | Ordinary Shares | |
| Leonard E. Post | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 2,382 | 2,382 (0%) | 0% | 0 | Ordinary Shares | |
| Leonard E. Post | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 4,107 | 4,107 | - | - | Stock Option (Right to Buy) | |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 4,107 | 4,107 | - | - | Stock Option (Right to Buy) | |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 2,382 | 10,450 (0%) | 0% | 0 | Ordinary Shares | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 96,229 | 96,229 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 55,813 | 278,751 (0%) | 0% | 0 | Ordinary Shares | |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 4,107 | 4,107 | - | - | Stock Option (Right to Buy) | |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 2,382 | 6,953 (0%) | 0% | 0 | Ordinary Shares | |
| Paula Soteropoulos | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 4,107 | 4,107 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 2,382 | 6,868 (0%) | 0% | 0 | Ordinary Shares | |
| Philip Astley-Sparke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 2,382 | 10,450 (0%) | 0% | 0 | Ordinary Shares | |
| Philip Astley-Sparke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 4,107 | 4,107 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 32,272 | 32,272 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 18,718 | 70,077 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 16,335 | 64,954 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 16,335 | 16,335 | - | - | Stock Option (Right to Buy) | |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 2,382 | 10,450 (0%) | 0% | 0 | Ordinary Shares | |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 4,107 | 4,107 | - | - | Stock Option (Right to Buy) | |
| Robert Gut | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 2,382 | 43,301 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Gut | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 4,107 | 4,107 | - | - | Stock Option (Right to Buy) | |
| Ricardo Dolmetsch | President, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 21,947 | 21,947 | - | - | Stock Option (Right to Buy) | |
| Ricardo Dolmetsch | President, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 12,729 | 77,729 (0%) | 0% | 0 | Ordinary Shares | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 35.97 per share. | 15 Feb 2021 | 1,750 | 222,938 (0%) | 0% | 36.0 | 62,948 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 34.88 per share. | 15 Feb 2021 | 2,050 | 224,688 (0%) | 0% | 34.9 | 71,504 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 35.49 per share. | 29 Jan 2021 | 6,116 | 227,622 (0%) | 0% | 35.5 | 217,057 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 36.19 per share. | 29 Jan 2021 | 884 | 226,738 (0%) | 0% | 36.2 | 31,992 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 37.57 per share. | 27 Jan 2021 | 9,339 | 249,788 (0%) | 0% | 37.6 | 350,866 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 36.86 per share. | 27 Jan 2021 | 1,701 | 233,738 (0%) | 0% | 36.9 | 62,699 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 35.96 per share. | 27 Jan 2021 | 14,049 | 235,439 (0%) | 0% | 36.0 | 505,202 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 38.18 per share. | 27 Jan 2021 | 300 | 249,488 (0%) | 0% | 38.2 | 11,454 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 36.86 per share. | 27 Jan 2021 | 1,701 | 233,738 (0%) | 0% | 36.9 | 62,699 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 35.96 per share. | 27 Jan 2021 | 14,049 | 235,439 (0%) | 0% | 36.0 | 505,202 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 38.18 per share. | 27 Jan 2021 | 300 | 249,488 (0%) | 0% | 38.2 | 11,454 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 37.57 per share. | 27 Jan 2021 | 9,339 | 249,788 (0%) | 0% | 37.6 | 350,866 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 36.59 per share. | 27 Jan 2021 | 6,110 | 259,127 (0%) | 0% | 36.6 | 223,565 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 36.59 per share. | 27 Jan 2021 | 6,110 | 259,127 (0%) | 0% | 36.6 | 223,565 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 39.01 per share. | 26 Jan 2021 | 713 | 56,147 (0%) | 0% | 39.0 | 27,814 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 37.23 per share. | 26 Jan 2021 | 4,788 | 51,359 (0%) | 0% | 37.2 | 178,257 | Ordinary Shares |
| Christian Klemt | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 39.00 per share. | 26 Jan 2021 | 952 | 56,066 (0%) | 0% | 39 | 37,128 | Ordinary Shares |
| Christian Klemt | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 37.38 per share. | 26 Jan 2021 | 7,447 | 48,619 (0%) | 0% | 37.4 | 278,369 | Ordinary Shares |
| Robert Gut | Director, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 39.09 per share. | 26 Jan 2021 | 604 | 40,919 (0%) | 0% | 39.1 | 23,610 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 48.34 per share. | 16 Dec 2020 | 10,715 | 267,023 (0%) | 0% | 48.3 | 517,963 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2020 | 12,501 | 58,817 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 48.83 per share. | 16 Dec 2020 | 1,786 | 265,237 (0%) | 0% | 48.8 | 87,210 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.53 per share. | 16 Dec 2020 | 12,501 | 277,738 (0%) | 0% | 7.5 | 94,133 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 45.18 per share. | 19 Nov 2020 | 11,355 | 265,237 (0%) | 0% | 45.2 | 513,019 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Nov 2020 | 3,125 | 71,318 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.53 per share. | 19 Nov 2020 | 3,125 | 276,592 (0%) | 0% | 7.5 | 23,531 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 43.11 per share. | 18 Nov 2020 | 3,937 | 279,843 (0%) | 0% | 43.1 | 169,724 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2020 | 3,216 | 74,443 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 44.71 per share. | 18 Nov 2020 | 600 | 273,467 (0%) | 0% | 44.7 | 26,826 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 43.98 per share. | 18 Nov 2020 | 5,776 | 274,067 (0%) | 0% | 44.0 | 254,028 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.53 per share. | 18 Nov 2020 | 3,216 | 283,780 (0%) | 0% | 7.5 | 24,216 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 36.49 per share. | 14 Oct 2020 | 300 | 280,564 (0%) | 0% | 36.5 | 10,947 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 35.82 per share. | 14 Oct 2020 | 4,950 | 280,864 (0%) | 0% | 35.8 | 177,309 | Ordinary Shares |
| Robert Gut | Director, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 39.12 per share. | 21 Sep 2020 | 4,352 | 41,523 (0%) | 0% | 39.1 | 170,250 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 41.18 per share. | 18 Sep 2020 | 2,230 | 56,860 (0%) | 0% | 41.2 | 91,831 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 41.31 per share. | 16 Sep 2020 | 2,129 | 285,933 (0%) | 0% | 41.3 | 87,949 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 42.18 per share. | 16 Sep 2020 | 119 | 285,814 (0%) | 0% | 42.2 | 5,019 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 40.36 per share. | 16 Sep 2020 | 5,252 | 288,062 (0%) | 0% | 40.4 | 211,971 | Ordinary Shares |
| Leonard E. Post | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Sep 2020 | 10,000 | 10,000 | - | - | Stock option (Right to Buy) | |
| Ricardo Dolmetsch | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Sep 2020 | 35,000 | 35,000 | - | - | Stock option (Right to Buy) | |
| Ricardo Dolmetsch | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Sep 2020 | 55,000 | 65,000 (0%) | 0% | 0 | Ordinary Shares | |
| Ricardo Dolmetsch | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Sep 2020 | 10,000 | 10,000 (0%) | 0% | 0 | Ordinary Shares | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 40.27 per share. | 25 Aug 2020 | 300 | 293,314 (0%) | 0% | 40.3 | 12,081 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 40.18 per share. | 19 Aug 2020 | 1,150 | 293,614 (0%) | 0% | 40.2 | 46,207 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 38.72 per share. | 19 Aug 2020 | 3,150 | 294,764 (0%) | 0% | 38.7 | 121,968 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 43.03 per share. | 22 Jul 2020 | 611 | 297,914 (0%) | 0% | 43.0 | 26,291 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 42.22 per share. | 22 Jul 2020 | 5,015 | 298,525 (0%) | 0% | 42.2 | 211,733 | Ordinary Shares |
| Robert Gut | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 39.97 per share. | 23 Jun 2020 | 21,875 | 72,750 (0%) | 0% | 40.0 | 874,344 | Ordinary Shares |
| Robert Gut | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jun 2020 | 21,875 | 48,125 | - | - | Stock Option (Right to Buy) | |
| Robert Gut | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jun 2020 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Robert Gut | Director, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 70.00 per share. | 23 Jun 2020 | 26,875 | 45,875 (0%) | 0% | 70 | 1,881,250 | Ordinary Shares |
| Robert Gut | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 35.40 per share. | 23 Jun 2020 | 5,000 | 50,875 (0%) | 0% | 35.4 | 177,000 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 66.47 per share. | 17 Jun 2020 | 3,492 | 303,840 (0%) | 0% | 66.5 | 232,113 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 66.97 per share. | 17 Jun 2020 | 300 | 303,540 (0%) | 0% | 67.0 | 20,091 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 65.56 per share. | 17 Jun 2020 | 3,709 | 307,332 (0%) | 0% | 65.6 | 243,162 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 59.88 per share. | 20 May 2020 | 6,801 | 311,741 (0%) | 0% | 59.9 | 407,244 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 60.48 per share. | 20 May 2020 | 700 | 311,041 (0%) | 0% | 60.5 | 42,336 | Ordinary Shares |
| Christian Klemt | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.41 per share. | 24 Apr 2020 | 2,250 | 59,268 (0%) | 0% | 26.4 | 59,423 | Ordinary Shares |
| Christian Klemt | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Apr 2020 | 2,250 | 0 | - | - | Stock Option (Right to Buy) | |
| Christian Klemt | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 24 Apr 2020 | 2,250 | 57,018 (0%) | 0% | 60 | 135,000 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.53 per share. | 22 Apr 2020 | 9,376 | 327,918 (0%) | 0% | 7.5 | 70,601 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Apr 2020 | 9,376 | 77,659 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 57.34 per share. | 22 Apr 2020 | 1,200 | 318,542 (0%) | 0% | 57.3 | 68,808 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 56.80 per share. | 22 Apr 2020 | 8,176 | 319,742 (0%) | 0% | 56.8 | 464,397 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 40.57 per share. | 18 Mar 2020 | 1,888 | 322,280 (0%) | 0% | 40.6 | 76,596 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2020 | 5,626 | 87,035 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 43.70 per share. | 18 Mar 2020 | 200 | 318,542 (0%) | 0% | 43.7 | 8,740 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 42.40 per share. | 18 Mar 2020 | 1,438 | 318,742 (0%) | 0% | 42.4 | 60,971 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.53 per share. | 18 Mar 2020 | 5,626 | 324,168 (0%) | 0% | 7.5 | 42,364 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 41.45 per share. | 18 Mar 2020 | 2,100 | 320,180 (0%) | 0% | 41.5 | 87,045 | Ordinary Shares |
| Christian Klemt | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 54.00 per share. | 04 Mar 2020 | 2,250 | 57,018 (0%) | 0% | 54 | 121,500 | Ordinary Shares |
| Christian Klemt | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2020 | 15,750 | 2,250 | - | - | Stock Option (Right to Buy) | |
| Christian Klemt | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.41 per share. | 04 Mar 2020 | 15,750 | 72,768 (0%) | 0% | 26.4 | 415,958 | Ordinary Shares |
| Christian Klemt | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 52.00 per share. | 04 Mar 2020 | 13,500 | 59,268 (0%) | 0% | 52 | 702,000 | Ordinary Shares |
| Jack Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 2,063 | 16,191 (0%) | 0% | 0 | Ordinary Shares | |
| Jack Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 3,620 | 3,620 | - | - | Stock Option (Right to Buy) | |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 3,620 | 3,620 | - | - | Stock Option (Right to Buy) | |
| Madhu Balachandran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 2,063 | 8,068 (0%) | 0% | 0 | Ordinary Shares | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 59,278 | 59,278 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 33,789 | 318,542 (0%) | 0% | 0 | Ordinary Shares | |
| Sander van Deventer | EVP, Research & Product Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 12,380 | 61,599 (0%) | 0% | 0 | Ordinary Shares | |
| Sander van Deventer | EVP, Research & Product Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 21,719 | 21,719 | - | - | Stock Option (Right to Buy) | |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 2,063 | 4,571 (0%) | 0% | 0 | Ordinary Shares | |
| David D. Meek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 3,620 | 3,620 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 3,620 | 3,620 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 2,063 | 4,486 (0%) | 0% | 0 | Ordinary Shares | |
| David Schaffer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 2,063 | 46,978 (0%) | 0% | 0 | Ordinary Shares | |
| David Schaffer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 3,620 | 3,620 | - | - | Stock Option (Right to Buy) | |
| Philip Astley-Sparke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 3,620 | 3,620 | - | - | Stock Option (Right to Buy) | |
| Philip Astley-Sparke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 2,063 | 8,068 (0%) | 0% | 0 | Ordinary Shares | |
| Alexander Edward Kuta | Executive VP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 12,380 | 59,090 (0%) | 0% | 0 | Ordinary Shares | |
| Alexander Edward Kuta | Executive VP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 21,719 | 21,719 | - | - | Stock Option (Right to Buy) | |
| Christian Klemt | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 8,253 | 57,018 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 14,479 | 14,479 | - | - | Stock Option (Right to Buy) | |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 2,063 | 8,068 (0%) | 0% | 0 | Ordinary Shares | |
| Jeremy P. Springhorn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 3,620 | 3,620 | - | - | Stock Option (Right to Buy) | |
| Robert Gut | Director, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 12,380 | 45,875 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Gut | Director, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 21,719 | 21,719 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 63.05 per share. | 19 Feb 2020 | 1,600 | 290,654 (0%) | 0% | 63.1 | 100,880 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 65.63 per share. | 19 Feb 2020 | 200 | 284,753 (0%) | 0% | 65.6 | 13,126 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 65.06 per share. | 19 Feb 2020 | 4,801 | 284,953 (0%) | 0% | 65.1 | 312,353 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 64.33 per share. | 19 Feb 2020 | 900 | 289,754 (0%) | 0% | 64.3 | 57,897 | Ordinary Shares |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 60.58 per share. | 05 Feb 2020 | 1,300 | 3,245 (0%) | 0% | 60.6 | 78,754 | Ordinary Shares |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 61.53 per share. | 05 Feb 2020 | 822 | 2,423 (0%) | 0% | 61.5 | 50,578 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2020 | 27,713 | 292,254 (0%) | 0% | 0 | Ordinary Shares | |
| Sander van Deventer | EVP, Research & Product Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2020 | 6,092 | 49,219 (0%) | 0% | 0 | Ordinary Shares | |
| Alexander Edward Kuta | Executive VP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2020 | 6,610 | 46,710 (0%) | 0% | 0 | Ordinary Shares | |
| Christian Klemt | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2020 | 6,201 | 48,765 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Gut | Director, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2020 | 5,610 | 33,495 (0%) | 0% | 0 | Ordinary Shares | |
| Philip Astley-Sparke | Director | Sale of securities on an exchange or to another person at price $ 59.23 per share. | 30 Jan 2020 | 807 | 6,005 (0%) | 0% | 59.2 | 47,799 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 57.98 per share. | 29 Jan 2020 | 3,872 | 264,541 (0%) | 0% | 58.0 | 224,499 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 61.11 per share. | 29 Jan 2020 | 300 | 268,413 (0%) | 0% | 61.1 | 18,333 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 60.58 per share. | 29 Jan 2020 | 2,354 | 268,713 (0%) | 0% | 60.6 | 142,605 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 59.45 per share. | 29 Jan 2020 | 11,744 | 271,067 (0%) | 0% | 59.5 | 698,181 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 58.74 per share. | 29 Jan 2020 | 9,185 | 282,811 (0%) | 0% | 58.7 | 539,527 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 62.89 per share. | 29 Jan 2020 | 600 | 291,996 (0%) | 0% | 62.9 | 37,734 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 62.01 per share. | 29 Jan 2020 | 18,383 | 292,596 (0%) | 0% | 62.0 | 1,139,930 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 61.55 per share. | 29 Jan 2020 | 4,600 | 310,979 (0%) | 0% | 61.6 | 283,130 | Ordinary Shares |
| Jack Kaye | Director | Sale of securities on an exchange or to another person at price $ 62.20 per share. | 28 Jan 2020 | 806 | 14,128 (0%) | 0% | 62.2 | 50,133 | Ordinary Shares |
| Madhu Balachandran | Director | Sale of securities on an exchange or to another person at price $ 62.20 per share. | 28 Jan 2020 | 807 | 6,005 (0%) | 0% | 62.2 | 50,195 | Ordinary Shares |
| Sander van Deventer | EVP, Research & Product Dev. | Sale of securities on an exchange or to another person at price $ 61.27 per share. | 28 Jan 2020 | 1,304 | 44,050 (0%) | 0% | 61.3 | 79,896 | Ordinary Shares |
| Sander van Deventer | EVP, Research & Product Dev. | Sale of securities on an exchange or to another person at price $ 62.10 per share. | 28 Jan 2020 | 923 | 43,127 (0%) | 0% | 62.1 | 57,318 | Ordinary Shares |
| David D. Meek | Director | Sale of securities on an exchange or to another person at price $ 61.00 per share. | 28 Jan 2020 | 4 | 3,226 (0%) | 0% | 61 | 244 | Ordinary Shares |
| David D. Meek | Director | Sale of securities on an exchange or to another person at price $ 62.20 per share. | 28 Jan 2020 | 718 | 2,508 (0%) | 0% | 62.2 | 44,660 | Ordinary Shares |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 62.19 per share. | 28 Jan 2020 | 807 | 4,545 (0%) | 0% | 62.2 | 50,187 | Ordinary Shares |
| David Schaffer | Director | Sale of securities on an exchange or to another person at price $ 62.27 per share. | 28 Jan 2020 | 806 | 44,915 (0%) | 0% | 62.3 | 50,190 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 62.15 per share. | 28 Jan 2020 | 1,469 | 40,100 (0%) | 0% | 62.1 | 91,298 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 61.11 per share. | 28 Jan 2020 | 9 | 41,569 (0%) | 0% | 61.1 | 550 | Ordinary Shares |
| Christian Klemt | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 61.28 per share. | 28 Jan 2020 | 8,942 | 45,597 (0%) | 0% | 61.3 | 547,966 | Ordinary Shares |
| Christian Klemt | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 62.02 per share. | 28 Jan 2020 | 3,033 | 42,564 (0%) | 0% | 62.0 | 188,107 | Ordinary Shares |
| Jeremy P. Springhorn | Director | Sale of securities on an exchange or to another person at price $ 61.00 per share. | 28 Jan 2020 | 4 | 6,808 (0%) | 0% | 61 | 244 | Ordinary Shares |
| Jeremy P. Springhorn | Director | Sale of securities on an exchange or to another person at price $ 62.20 per share. | 28 Jan 2020 | 803 | 6,005 (0%) | 0% | 62.2 | 49,947 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 69.94 per share. | 27 Jan 2020 | 13,207 | 352,868 (0%) | 0% | 69.9 | 923,698 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 61.86 per share. | 27 Jan 2020 | 13,106 | 339,762 (0%) | 0% | 61.9 | 810,737 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 59.87 per share. | 27 Jan 2020 | 1,376 | 366,075 (0%) | 0% | 59.9 | 82,381 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 62.80 per share. | 27 Jan 2020 | 1,400 | 315,579 (0%) | 0% | 62.8 | 87,920 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 62.42 per share. | 27 Jan 2020 | 11,707 | 316,979 (0%) | 0% | 62.4 | 730,751 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 61.24 per share. | 27 Jan 2020 | 10,476 | 328,686 (0%) | 0% | 61.2 | 641,550 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 62.44 per share. | 27 Jan 2020 | 600 | 339,162 (0%) | 0% | 62.4 | 37,464 | Ordinary Shares |
| Robert Gut | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 62.19 per share. | 27 Jan 2020 | 596 | 27,885 (0%) | 0% | 62.2 | 37,065 | Ordinary Shares |
| Robert Gut | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 60.01 per share. | 27 Jan 2020 | 6,897 | 28,481 (0%) | 0% | 60.0 | 413,889 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 15 Jan 2020 | 4,000 | 45,578 (0%) | 0% | 5.3 | 21,240 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2020 | 4,000 | 98,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 68.97 per share. | 15 Jan 2020 | 4,000 | 41,578 (0%) | 0% | 69.0 | 275,880 | Ordinary Shares |
| Paula Soteropoulos | Director | Sale of securities on an exchange or to another person at price $ 72.18 per share. | 07 Jan 2020 | 3,000 | 5,352 (0%) | 0% | 72.2 | 216,540 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.53 per share. | 18 Dec 2019 | 7,339 | 374,991 (0%) | 0% | 7.5 | 55,263 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2019 | 7,339 | 92,661 | - | - | Stock Option (Right to Buy) | |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 71.70 per share. | 18 Dec 2019 | 276 | 367,451 (0%) | 0% | 71.7 | 19,789 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 70.55 per share. | 18 Dec 2019 | 1,110 | 367,727 (0%) | 0% | 70.6 | 78,311 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 69.94 per share. | 18 Dec 2019 | 6,154 | 368,837 (0%) | 0% | 69.9 | 430,411 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 74.37 per share. | 16 Dec 2019 | 3,276 | 42,302 (0%) | 0% | 74.4 | 243,636 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2019 | 4,000 | 102,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 75.58 per share. | 16 Dec 2019 | 724 | 41,578 (0%) | 0% | 75.6 | 54,720 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 16 Dec 2019 | 4,000 | 45,578 (0%) | 0% | 5.3 | 21,240 | Ordinary Shares |
| Paula Soteropoulos | None | Sale of securities on an exchange or to another person at price $ 70.50 per share. | 13 Dec 2019 | 2,000 | 8,352 (0%) | 0% | 70.5 | 141,000 | Ordinary Shares |
| Paula Soteropoulos | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2019 | 2,000 | 9,000 | - | - | Stock Option (Right to Buy) | |
| Paula Soteropoulos | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.37 per share. | 13 Dec 2019 | 2,000 | 10,352 (0%) | 0% | 5.4 | 10,740 | Ordinary Shares |
| Paula Soteropoulos | None | Sale of securities on an exchange or to another person at price $ 64.39 per share. | 06 Dec 2019 | 7,382 | 10,852 (0%) | 0% | 64.4 | 475,327 | Ordinary Shares |
| Paula Soteropoulos | None | Sale of securities on an exchange or to another person at price $ 67.50 per share. | 06 Dec 2019 | 2,500 | 8,352 (0%) | 0% | 67.5 | 168,750 | Ordinary Shares |
| Paula Soteropoulos | None | Sale of securities on an exchange or to another person at price $ 63.69 per share. | 06 Dec 2019 | 1,700 | 18,234 (0%) | 0% | 63.7 | 108,273 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 54.09 per share. | 20 Nov 2019 | 3,500 | 368,852 (0%) | 0% | 54.1 | 189,315 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 54.67 per share. | 20 Nov 2019 | 1,200 | 367,652 (0%) | 0% | 54.7 | 65,604 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 53.04 per share. | 20 Nov 2019 | 3,300 | 372,352 (0%) | 0% | 53.0 | 175,032 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 51.99 per share. | 15 Nov 2019 | 3,500 | 42,078 (0%) | 0% | 52.0 | 181,965 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2019 | 4,000 | 106,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 52.69 per share. | 15 Nov 2019 | 500 | 41,578 (0%) | 0% | 52.7 | 26,345 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 15 Nov 2019 | 4,000 | 45,578 (0%) | 0% | 5.3 | 21,240 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 43.65 per share. | 23 Oct 2019 | 3,184 | 375,652 (0%) | 0% | 43.7 | 138,982 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 42.94 per share. | 23 Oct 2019 | 4,816 | 378,836 (0%) | 0% | 42.9 | 206,799 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 42.35 per share. | 15 Oct 2019 | 4,000 | 41,578 (0%) | 0% | 42.4 | 169,400 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2019 | 4,000 | 110,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 15 Oct 2019 | 4,000 | 45,578 (0%) | 0% | 5.3 | 21,240 | Ordinary Shares |
| Robert Gut | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 47.16 per share. | 19 Sep 2019 | 4,769 | 35,378 (0%) | 0% | 47.2 | 224,906 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 48.38 per share. | 18 Sep 2019 | 77 | 383,652 (0%) | 0% | 48.4 | 3,725 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 47.58 per share. | 18 Sep 2019 | 1,841 | 383,729 (0%) | 0% | 47.6 | 87,595 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 46.69 per share. | 18 Sep 2019 | 3,008 | 385,570 (0%) | 0% | 46.7 | 140,444 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 47.73 per share. | 18 Sep 2019 | 3,074 | 388,578 (0%) | 0% | 47.7 | 146,722 | Ordinary Shares |
| Sander van Deventer | EVP, Research & Product Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Sep 2019 | 15,000 | 45,354 (0%) | 0% | 0 | Ordinary Shares | |
| Alexander Edward Kuta | Executive VP, Operations | Sale of securities on an exchange or to another person at price $ 47.26 per share. | 16 Sep 2019 | 4,000 | 26,578 (0%) | 0% | 47.3 | 189,040 | Ordinary Shares |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2019 | 4,000 | 114,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Edward Kuta | Executive VP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2019 | 15,000 | 41,578 (0%) | 0% | 0 | Ordinary Shares | |
| Alexander Edward Kuta | Executive VP, Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.31 per share. | 16 Sep 2019 | 4,000 | 30,578 (0%) | 0% | 5.3 | 21,240 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 56.48 per share. | 21 Aug 2019 | 8,000 | 391,230 (0%) | 0% | 56.5 | 451,840 | Ordinary Shares |
| Philip Astley-Sparke | None | Sale of securities on an exchange or to another person at price $ 59.30 per share. | 01 Aug 2019 | 1,400 | 11,006 (0%) | 0% | 59.3 | 83,020 | Ordinary Shares |
| Philip Astley-Sparke | None | Sale of securities on an exchange or to another person at price $ 61.15 per share. | 01 Aug 2019 | 1,200 | 6,812 (0%) | 0% | 61.2 | 73,380 | Ordinary Shares |
| Philip Astley-Sparke | None | Sale of securities on an exchange or to another person at price $ 60.65 per share. | 01 Aug 2019 | 2,994 | 8,012 (0%) | 0% | 60.6 | 181,586 | Ordinary Shares |
| Philip Astley-Sparke | None | Sale of securities on an exchange or to another person at price $ 58.15 per share. | 01 Aug 2019 | 866 | 12,406 (0%) | 0% | 58.2 | 50,358 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 70.69 per share. | 17 Jul 2019 | 1,000 | 403,839 (0%) | 0% | 70.7 | 70,690 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 72.70 per share. | 17 Jul 2019 | 2,500 | 399,230 (0%) | 0% | 72.7 | 181,750 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 71.98 per share. | 17 Jul 2019 | 2,109 | 401,730 (0%) | 0% | 72.0 | 151,806 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 70.00 per share. | 17 Jul 2019 | 2,391 | 404,839 (0%) | 0% | 70 | 167,370 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 77.97 per share. | 19 Jun 2019 | 2,177 | 407,230 (0%) | 0% | 78.0 | 169,741 | Ordinary Shares |
| Matthew C. Kapusta | Director, CEO, CFO, Managing Director | Sale of securities on an exchange or to another person at price $ 77.26 per share. | 19 Jun 2019 | 5,823 | 409,407 (0%) | 0% | 77.3 | 449,885 | Ordinary Shares |
| Philip Astley-Sparke | None | Sale of securities on an exchange or to another person at price $ 62.97 per share. | 03 Jun 2019 | 600 | 18,272 (0%) | 0% | 63.0 | 37,782 | Ordinary Shares |
| Philip Astley-Sparke | None | Sale of securities on an exchange or to another person at price $ 64.53 per share. | 03 Jun 2019 | 599 | 13,272 (0%) | 0% | 64.5 | 38,653 | Ordinary Shares |